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How Vitamin B12 Triggers Acne Lesions

Aug 30, 2018
1 min read

Updated: Mar 5, 2025



Recent research has revealed that the infamous acne bacteria (P. acnes), Vitamin B12, and the skin microbiome are closely related.


The research found that when B12 is taken as a supplement, these bacteria stopped producing their own amount and instead began producing porphyrin molecules. Porphyrins can generate inflammation, and inflammation triggers acne at the beginning. Vitamin B12 alters the normal metabolic pathway and activity of the skin bacteria. Moreover, B12 supplementation can make someone with clear skin start breaking out. Evidenced by the increase in acne breakouts post vitamin B12 supplementation. When there is an elevated B12 level, it leads to an overproduction of porphyrins by P. acnes. Porphyrins can induce inflammation and acne lesions.


The Bottom Line


Too much of a good thing can be problematic. Avoid supplements with high doses of vitamin B12 (i.e., 500% daily value). For those of you that already have low-B12 levels or are vegan or vegetarians, there are different alternatives to increase these levels without having to take an oral supplement and triggering acne breakouts.


For more information, contact us for a worldwide skin consultation HERE.


 
 

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The information provided on this website and through Integrative Aesthetics Boston is intended for general educational and informational purposes only and should not be considered individualized medical advice. Integrative Aesthetics Boston is a functional dermatology and integrative skincare practice led by a licensed Nurse Practitioner. Clinical evaluation, diagnosis, treatment, prescriptions, laboratory testing, skincare recommendations, procedures, and other services are provided only when appropriate within an established clinician-patient relationship and within the practitioner’s professional scope of practice. Website content does not establish a clinician-patient relationship and should not be used as a substitute for individualized evaluation by a qualified healthcare professional. If you have, or suspect that you have, a medical condition, please seek appropriate medical care. Do not start, stop, or change medications, supplements, nutrition, or other aspects of your medical care without guidance from a qualified healthcare professional. Integrative Aesthetics Boston may collaborate with or refer patients to dermatologists, primary care providers, and other qualified healthcare professionals when clinically appropriate. Individual results vary and cannot be guaranteed. Integrative Aesthetics Boston does not provide emergency or urgent-care services. If you are experiencing a medical emergency or severe or rapidly worsening symptoms, call 911 or seek immediate care through an emergency department or appropriate urgent-care provider. Statements regarding dietary supplements have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent disease.

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