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How Vitamin B12 Triggers Acne Lesions

Updated: Mar 5, 2025



Recent research has revealed that the infamous acne bacteria (P. acnes), Vitamin B12, and the skin microbiome are closely related.


The research found that when B12 is taken as a supplement, these bacteria stopped producing their own amount and instead began producing porphyrin molecules. Porphyrins can generate inflammation, and inflammation triggers acne at the beginning. Vitamin B12 alters the normal metabolic pathway and activity of the skin bacteria. Moreover, B12 supplementation can make someone with clear skin start breaking out. Evidenced by the increase in acne breakouts post vitamin B12 supplementation. When there is an elevated B12 level, it leads to an overproduction of porphyrins by P. acnes. Porphyrins can induce inflammation and acne lesions.


The Bottom Line


Too much of a good thing can be problematic. Avoid supplements with high doses of vitamin B12 (i.e., 500% daily value). For those of you that already have low-B12 levels or are vegan or vegetarians, there are different alternatives to increase these levels without having to take an oral supplement and triggering acne breakouts.


For more information, contact us for a worldwide skin consultation HERE.


 
 

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Disclaimer:
The information shared on this website and throughout Integrative Aesthetics Boston is provided for educational and informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease, nor should it be used as a substitute for medical advice from your physician or other qualified healthcare provider. Functional Dermatology and Integrative Wellness services offered through Integrative Aesthetics Boston are designed to support skin and whole-body health from a root-cause perspective and are provided in collaboration with licensed medical professionals when appropriate. No information presented here should be interpreted as medical advice or as establishing a clinician-patient relationship between you and any practitioner affiliated with this website. If you have, or suspect that you have, a medical condition, please contact your healthcare provider promptly. Always seek the guidance of your qualified healthcare professional before making any changes to your medical care, including medications, supplements, nutrition, or lifestyle practices. Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure, or prevent any disease.

 

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